F17S (p.Phe17Ser) variant of RAF1 (P04049)
F17S (p.Phe17Ser) in RAF1 (P04049) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.37 / 1. The record also includes experimental measurements and structural context.
F17S (p.Phe17Ser) variant details
- p.Phe17Ser
- rs1454494958
- NCI-TCGA Cosmic COSV5258
- cosmic curated COSV52580
- gnomAD rs1454494958
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.371
- AlphaMissense 0.16
- MetaLR 0.25
- MetaSVM -0.74
- PolyPhen-2 0.02
- SIFT 0.08
- MutPred 0.41
- UniProt: Variant assessed as somatic; moderate impact.
- Structural context available
- RAF1 Raf-like Ras-binding domain domainome 1.0: score -0.0374