F15H (p.Phe15His) variant of RAF1 (P04049)
F15H (p.Phe15His) in RAF1 (P04049) is a protein-truncating change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.32 / 1. The record also includes population frequency data, experimental measurements, published literature, and structural context.
F15H (p.Phe15His) variant details
- p.Phe15His
- gnomAD 14-20891699-CTG-C
- Frameshift
- Variant Prioritization Score for Impact Estimate 0.318
- CADD 21.20
- Most common in the East Asian population (allele frequency 2.5e-05)
- Structural context available
- RAF1 Raf-like Ras-binding domain domainome 1.0: score -0.771
- Literature evidence available