A20V (p.Ala20Val) variant of RAF1 (P04049)
A20V (p.Ala20Val) in RAF1 (P04049) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.37 / 1. The record also includes population frequency data, experimental measurements, and structural context.
A20V (p.Ala20Val) variant details
- p.Ala20Val
- rs1438827623
- NCI-TCGA Cosmic COSV5258
- cosmic curated COSV52582
- TOPMed rs1438827623
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.369
- AlphaMissense 0.09
- MetaLR 0.26
- MetaSVM -0.75
- PolyPhen-2 0.01
- SIFT 0.01
- MutPred 0.19
- UniProt: Variant assessed as somatic; moderate impact.
- Population evidence available
- Structural context available
- RAF1 Raf-like Ras-binding domain domainome 1.0: score -0.454