G12R (p.Gly12Arg) variant of RAC1 (P63000)
G12R (p.Gly12Arg) in RAC1 (P63000) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.67 / 1. The record also includes population frequency data and structural context.
G12R (p.Gly12Arg) variant details
- p.Gly12Arg
- cosmic curated COSV61822
- NCI-TCGA Cosmic COSV6182
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.674
- REVEL 0.74
- CADD 26.40
- PolyPhen-2 0.74
- SIFT 0.02
- UniProt: Variant assessed as somatic; moderate impact.
- Population evidence available
- Structural context available