T27A (p.Thr27Ala) variant of PTPN4 (P29074)
T27A (p.Thr27Ala) in PTPN4 (P29074) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.37 / 1. The record also includes population frequency data, published literature, and structural context.
T27A (p.Thr27Ala) variant details
- p.Thr27Ala
- gnomAD 2-119809932-A-G
- Missense
- Variant Prioritization Score for Impact Estimate 0.371
- REVEL 0.25
- ESM-1b 0.61
- AlphaMissense 0.06
- MetaLR 0.25
- MetaSVM -0.73
- CADD 22.00
- Most common in the Latino/Admixed American population (allele frequency 2.2e-05)
- Structural context available
- Literature evidence available