L64F (p.Leu64Phe) variant of PTPN4 (P29074)
L64F (p.Leu64Phe) in PTPN4 (P29074) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.75 / 1. The record also includes population frequency data and structural context.
L64F (p.Leu64Phe) variant details
- p.Leu64Phe
- rs1351098041
- NCI-TCGA Cosmic COSV5529
- gnomAD rs1351098041
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.754
- REVEL 0.84
- ESM-1b 1.00
- AlphaMissense 0.65
- MetaLR 0.77
- MetaSVM 0.74
- CADD 24.40
- UniProt: Variant assessed as somatic; moderate impact.
- Population evidence available
- Structural context available