Y32C (p.Tyr32Cys) variant of PTPN2 (P17706)
Y32C (p.Tyr32Cys) in PTPN2 (P17706) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.29 / 1. The record also includes population frequency data and structural context.
Y32C (p.Tyr32Cys) variant details
- p.Tyr32Cys
- cosmic curated COSV10737
- TOPMed rs1027932038
- gnomAD rs1027932038
- Missense
- Variant Prioritization Score for Impact Estimate 0.291
- REVEL 0.07
- CADD 22.70
- PolyPhen-2 0.03
- SIFT 0.20
- Most common in the African/African-American population (allele frequency 9.6e-05)
- Structural context available