R35S (p.Arg35Ser) variant of PTPN2 (P17706)
R35S (p.Arg35Ser) in PTPN2 (P17706) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.30 / 1. The record also includes population frequency data and structural context.
R35S (p.Arg35Ser) variant details
- p.Arg35Ser
- ExAC rs750374603
- TOPMed rs750374603
- gnomAD rs750374603
- Missense
- Variant Prioritization Score for Impact Estimate 0.3
- REVEL 0.08
- CADD 24.20
- PolyPhen-2 0.03
- SIFT 0.03
- Most common in the Non-Finnish European population (allele frequency 3.6e-06)
- Structural context available