R35G (p.Arg35Gly) variant of PTPN2 (P17706)
R35G (p.Arg35Gly) in PTPN2 (P17706) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.30 / 1. The record also includes population frequency data and structural context.
R35G (p.Arg35Gly) variant details
- p.Arg35Gly
- cosmic curated COSV58998
- TOPMed rs2043703320
- Missense
- Variant Prioritization Score for Impact Estimate 0.299
- REVEL 0.14
- CADD 24.70
- PolyPhen-2 0.09
- SIFT 0.01
- Most common in the African/African-American population (allele frequency 3e-05)
- Structural context available