L23S (p.Leu23Ser) variant of PTPN2 (P17706)
L23S (p.Leu23Ser) in PTPN2 (P17706) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.30 / 1. The record also includes population frequency data and structural context.
L23S (p.Leu23Ser) variant details
- p.Leu23Ser
- TOPMed rs2044773454
- Missense
- Variant Prioritization Score for Impact Estimate 0.302
- REVEL 0.21
- CADD 22.40
- PolyPhen-2 0.00
- SIFT 0.57
- Most common in the REMAINING population (allele frequency 3.4e-05)
- Structural context available