L23F (p.Leu23Phe) variant of PTPN2 (P17706)
L23F (p.Leu23Phe) in PTPN2 (P17706) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.33 / 1. The record also includes population frequency data and structural context.
L23F (p.Leu23Phe) variant details
- p.Leu23Phe
- TOPMed rs1457235029
- gnomAD rs1457235029
- Missense
- Variant Prioritization Score for Impact Estimate 0.334
- REVEL 0.06
- CADD 23.20
- PolyPhen-2 0.03
- SIFT 0.61
- Most common in the Latino/Admixed American population (allele frequency 6.5e-05)
- Structural context available