G445R (p.Gly445Arg) variant of PTCH1 (Protein patched homolog 1)

G445R (p.Gly445Arg) in PTCH1 (Protein patched homolog 1) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as likely pathogenic in the context of Gorlin syndrome. The record also includes structural context.

G445R (p.Gly445Arg) variant details