T25I (p.Thr25Ile) variant of PSEN1 (Presenilin-1)
T25I (p.Thr25Ile) in PSEN1 (Presenilin-1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.43 / 1. The record also includes population frequency data and structural context.
T25I (p.Thr25Ile) variant details
- p.Thr25Ile
- gnomAD rs201945418
- Missense
- Variant Prioritization Score for Impact Estimate 0.426
- REVEL 0.50
- CADD 15.10
- PolyPhen-2 0.00
- SIFT 0.43
- Most common in the Non-Finnish European population (allele frequency 4.5e-06)
- Structural context available