R41P (p.Arg41Pro) variant of PROS1 (Vitamin K-dependent protein S)
R41P (p.Arg41Pro) in PROS1 (Vitamin K-dependent protein S) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact in the context of in THPH5. The available variant effect predictions contribute to a CATVariant prioritization score of 0.84 / 1. The record also includes population frequency data.
R41P (p.Arg41Pro) variant details
- p.Arg41Pro
- NCI-TCGA Cosmic COSV6239
- Variant assessed as somatic; moderate impact.
- in THPH5
- Missense
- Variant Prioritization Score for Impact Estimate 0.841
- REVEL 0.89
- CADD 26.10
- PolyPhen-2 1.00
- SIFT 0.00
- UniProt: Variant assessed as somatic; moderate impact. (in THPH5)
- Most common in the Non-Finnish European population (allele frequency 3.6e-06)