R101H (p.Arg101His) variant of PROS1 (Vitamin K-dependent protein S)
R101H (p.Arg101His) in PROS1 (Vitamin K-dependent protein S) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.31 / 1. The record also includes population frequency data.
R101H (p.Arg101His) variant details
- p.Arg101His
- TOPMed rs1470600953
- gnomAD rs1470600953
- Missense
- Variant Prioritization Score for Impact Estimate 0.312
- REVEL 0.31
- CADD 22.60
- PolyPhen-2 0.99
- SIFT 0.07
- Most common in the Ashkenazi Jewish population (allele frequency 3.8e-05)