N105S (p.Asn105Ser) variant of PROS1 (Vitamin K-dependent protein S)
N105S (p.Asn105Ser) in PROS1 (Vitamin K-dependent protein S) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.27 / 1. The record also includes population frequency data.
N105S (p.Asn105Ser) variant details
- p.Asn105Ser
- rs372589167
- ESP rs372589167
- TOPMed rs372589167
- gnomAD rs372589167
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.272
- REVEL 0.19
- CADD 13.20
- PolyPhen-2 0.06
- SIFT 0.24
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 2.9e-05)