L27F (p.Leu27Phe) variant of PROS1 (Vitamin K-dependent protein S)
L27F (p.Leu27Phe) in PROS1 (Vitamin K-dependent protein S) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.40 / 1. The record also includes population frequency data.
L27F (p.Leu27Phe) variant details
- p.Leu27Phe
- 1000Genomes rs200631087
- Missense
- Variant Prioritization Score for Impact Estimate 0.404
- REVEL 0.48
- CADD 20.00
- PolyPhen-2 0.41
- SIFT 0.03
- Most common in the Non-Finnish European population (allele frequency 9e-07)