L16F (p.Leu16Phe) variant of PROS1 (Vitamin K-dependent protein S)
L16F (p.Leu16Phe) in PROS1 (Vitamin K-dependent protein S) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.26 / 1. The record also includes population frequency data.
L16F (p.Leu16Phe) variant details
- p.Leu16Phe
- gnomAD rs1323575023
- Missense
- Variant Prioritization Score for Impact Estimate 0.263
- REVEL 0.29
- CADD 7.62
- PolyPhen-2 0.05
- SIFT 0.44
- Most common in the Non-Finnish European population (allele frequency 1.8e-06)