L110I (p.Leu110Ile) variant of PROS1 (Vitamin K-dependent protein S)
L110I (p.Leu110Ile) in PROS1 (Vitamin K-dependent protein S) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.51 / 1. The record also includes population frequency data.
L110I (p.Leu110Ile) variant details
- p.Leu110Ile
- NCI-TCGA Cosmic COSV6239
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.505
- REVEL 0.57
- CADD 24.00
- PolyPhen-2 0.99
- SIFT 0.01
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Finnish in Finland (FIN) population (allele frequency 3.7e-05)