K84E (p.Lys84Glu) variant of PROS1 (Vitamin K-dependent protein S)
K84E (p.Lys84Glu) in PROS1 (Vitamin K-dependent protein S) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.69 / 1. The record also includes population frequency data.
K84E (p.Lys84Glu) variant details
- p.Lys84Glu
- TOPMed rs1187533518
- gnomAD rs1187533518
- Missense
- Variant Prioritization Score for Impact Estimate 0.695
- REVEL 0.82
- CADD 24.90
- PolyPhen-2 0.48
- SIFT 0.00
- Most common in the Latino/Admixed American population (allele frequency 6.5e-05)