K65E (p.Lys65Glu) variant of PROS1 (Vitamin K-dependent protein S)
K65E (p.Lys65Glu) in PROS1 (Vitamin K-dependent protein S) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.74 / 1. The record also includes population frequency data.
K65E (p.Lys65Glu) variant details
- p.Lys65Glu
- NCI-TCGA Cosmic COSV6239
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.742
- REVEL 0.81
- CADD 27.40
- PolyPhen-2 0.97
- SIFT 0.00
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 9e-07)