G9R (p.Gly9Arg) variant of PROS1 (Vitamin K-dependent protein S)
G9R (p.Gly9Arg) in PROS1 (Vitamin K-dependent protein S) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.29 / 1. The record also includes population frequency data.
G9R (p.Gly9Arg) variant details
- p.Gly9Arg
- gnomAD rs1189852497
- NCI-TCGA Cosmic COSV1007
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.292
- REVEL 0.12
- CADD 7.40
- PolyPhen-2 0.00
- SIFT 0.44
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 9e-07)