F92C (p.Phe92Cys) variant of PROS1 (Vitamin K-dependent protein S)
F92C (p.Phe92Cys) in PROS1 (Vitamin K-dependent protein S) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.56 / 1. The record also includes population frequency data.
F92C (p.Phe92Cys) variant details
- p.Phe92Cys
- ExAC rs772748769
- gnomAD rs772748769
- Missense
- Variant Prioritization Score for Impact Estimate 0.557
- REVEL 0.66
- CADD 24.20
- PolyPhen-2 0.99
- SIFT 0.01
- Most common in the Non-Finnish European population (allele frequency 3.6e-06)