C14Y (p.Cys14Tyr) variant of PROS1 (Vitamin K-dependent protein S)
C14Y (p.Cys14Tyr) in PROS1 (Vitamin K-dependent protein S) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.43 / 1. The record also includes population frequency data.
C14Y (p.Cys14Tyr) variant details
- p.Cys14Tyr
- ExAC rs771394908
- gnomAD rs771394908
- Missense
- Variant Prioritization Score for Impact Estimate 0.434
- REVEL 0.41
- CADD 17.00
- PolyPhen-2 0.28
- SIFT 0.10
- Most common in the South Asian population (allele frequency 1.2e-05)