W83L (p.Trp83Leu) variant of PROC (Vitamin K-dependent protein C)
W83L (p.Trp83Leu) in PROC (Vitamin K-dependent protein C) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.77 / 1. The record also includes population frequency data, published literature, and structural context.
W83L (p.Trp83Leu) variant details
- p.Trp83Leu
- gnomAD 2-127422927-G-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.769
- REVEL 0.80
- CADD 33.00
- PolyPhen-2 1.00
- SIFT 0.01
- Most common in the Non-Finnish European population (allele frequency 1.8e-06)
- Structural context available
- Literature evidence available