V36M (p.Val36Met) variant of PROC (Vitamin K-dependent protein C)
V36M (p.Val36Met) in PROC (Vitamin K-dependent protein C) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.46 / 1. The record also includes population frequency data, published literature, and structural context.
V36M (p.Val36Met) variant details
- p.Val36Met
- gnomAD 2-127421318-G-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.461
- REVEL 0.55
- CADD 23.10
- PolyPhen-2 0.17
- SIFT 0.02
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- Literature evidence available