V11E (p.Val11Glu) variant of PROC (Vitamin K-dependent protein C)
V11E (p.Val11Glu) in PROC (Vitamin K-dependent protein C) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.46 / 1. The record also includes population frequency data, published literature, and structural context.
V11E (p.Val11Glu) variant details
- p.Val11Glu
- gnomAD 2-127419974-T-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.46
- REVEL 0.53
- CADD 18.10
- PolyPhen-2 0.07
- SIFT 0.01
- Most common in the Latino/Admixed American population (allele frequency 2.2e-05)
- Structural context available
- Literature evidence available