P22L (p.Pro22Leu) variant of PROC (Vitamin K-dependent protein C)
P22L (p.Pro22Leu) in PROC (Vitamin K-dependent protein C) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.24 / 1. The record also includes population frequency data and structural context.
P22L (p.Pro22Leu) variant details
- p.Pro22Leu
- ExAC rs775126434
- gnomAD rs775126434
- Missense
- Variant Prioritization Score for Impact Estimate 0.244
- REVEL 0.29
- CADD 5.66
- PolyPhen-2 0.08
- SIFT 0.19
- Most common in the Non-Finnish European population (allele frequency 1.8e-06)
- Structural context available