P22A (p.Pro22Ala) variant of PROC (Vitamin K-dependent protein C)
P22A (p.Pro22Ala) in PROC (Vitamin K-dependent protein C) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.26 / 1. The record also includes population frequency data and structural context.
P22A (p.Pro22Ala) variant details
- p.Pro22Ala
- ExAC rs771569764
- TOPMed rs771569764
- gnomAD rs771569764
- Missense
- Variant Prioritization Score for Impact Estimate 0.265
- REVEL 0.27
- CADD 0.73
- PolyPhen-2 0.01
- SIFT 0.40
- Most common in the South Asian population (allele frequency 0.0002)
- Structural context available