L37V (p.Leu37Val) variant of PROC (Vitamin K-dependent protein C)
L37V (p.Leu37Val) in PROC (Vitamin K-dependent protein C) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.62 / 1. The record also includes population frequency data and structural context.
L37V (p.Leu37Val) variant details
- p.Leu37Val
- ExAC rs780914969
- gnomAD rs780914969
- Missense
- Variant Prioritization Score for Impact Estimate 0.617
- REVEL 0.68
- CADD 23.30
- PolyPhen-2 1.00
- SIFT 0.00
- Most common in the Latino/Admixed American population (allele frequency 2.2e-05)
- Structural context available