L37P (p.Leu37Pro) variant of PROC (Vitamin K-dependent protein C)
L37P (p.Leu37Pro) in PROC (Vitamin K-dependent protein C) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.79 / 1. The record also includes population frequency data and structural context.
L37P (p.Leu37Pro) variant details
- p.Leu37Pro
- ExAC rs748083494
- gnomAD rs748083494
- Missense
- Variant Prioritization Score for Impact Estimate 0.792
- REVEL 0.91
- CADD 25.80
- PolyPhen-2 1.00
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available