K70R (p.Lys70Arg) variant of PROC (Vitamin K-dependent protein C)
K70R (p.Lys70Arg) in PROC (Vitamin K-dependent protein C) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.43 / 1. The record also includes population frequency data and structural context.
K70R (p.Lys70Arg) variant details
- p.Lys70Arg
- ExAC rs568473236
- TOPMed rs568473236
- gnomAD rs568473236
- Missense
- Variant Prioritization Score for Impact Estimate 0.426
- REVEL 0.35
- CADD 13.80
- PolyPhen-2 0.01
- SIFT 1.00
- Most common in the Non-Finnish European population (allele frequency 1.8e-06)
- Structural context available