I63T (p.Ile63Thr) variant of PROC (Vitamin K-dependent protein C)
I63T (p.Ile63Thr) in PROC (Vitamin K-dependent protein C) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.26 / 1. The record also includes population frequency data and structural context.
I63T (p.Ile63Thr) variant details
- p.Ile63Thr
- TOPMed rs1370099703
- Missense
- Variant Prioritization Score for Impact Estimate 0.261
- REVEL 0.33
- CADD 12.60
- PolyPhen-2 0.02
- SIFT 0.63
- Most common in the Middle Eastern population (allele frequency 0.00017)
- Structural context available