I63F (p.Ile63Phe) variant of PROC (Vitamin K-dependent protein C)
I63F (p.Ile63Phe) in PROC (Vitamin K-dependent protein C) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.40 / 1. The record also includes population frequency data and structural context.
I63F (p.Ile63Phe) variant details
- p.Ile63Phe
- TOPMed rs1438849881
- Missense
- Variant Prioritization Score for Impact Estimate 0.396
- REVEL 0.53
- CADD 19.10
- PolyPhen-2 0.61
- SIFT 0.06
- Most common in the Non-Finnish European population (allele frequency 1.1e-05)
- Structural context available