I60T (p.Ile60Thr) variant of PROC (Vitamin K-dependent protein C)
I60T (p.Ile60Thr) in PROC (Vitamin K-dependent protein C) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.26 / 1. The record also includes population frequency data and structural context.
I60T (p.Ile60Thr) variant details
- p.Ile60Thr
- ExAC rs751218842
- TOPMed rs751218842
- gnomAD rs751218842
- Missense
- Variant Prioritization Score for Impact Estimate 0.258
- REVEL 0.40
- CADD 0.15
- PolyPhen-2 0.12
- SIFT 0.40
- Most common in the African/African-American population (allele frequency 4.8e-05)
- Structural context available