F66L (p.Phe66Leu) variant of PROC (Vitamin K-dependent protein C)
F66L (p.Phe66Leu) in PROC (Vitamin K-dependent protein C) is a missense change. Clinical records from EBI and UniProt describe it as likely benign. The available variant effect predictions contribute to a CATVariant prioritization score of 0.24 / 1. The record also includes population frequency data and structural context.
F66L (p.Phe66Leu) variant details
- p.Phe66Leu
- 1000Genomes rs201463891
- ExAC rs201463891
- TOPMed rs201463891
- gnomAD rs201463891
- Likely benign
- Missense
- Variant Prioritization Score for Impact Estimate 0.241
- REVEL 0.36
- CADD 2.30
- PolyPhen-2 0.09
- SIFT 0.24
- EBI: Likely benign
- UniProt: Likely benign
- Most common in the 1KG:MXL population (allele frequency 0.0081)
- Structural context available