C59Y (p.Cys59Tyr) variant of PROC (Vitamin K-dependent protein C)
C59Y (p.Cys59Tyr) in PROC (Vitamin K-dependent protein C) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.88 / 1. The record also includes population frequency data, published literature, and structural context.
C59Y (p.Cys59Tyr) variant details
- p.Cys59Tyr
- gnomAD 2-127421388-G-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.876
- REVEL 0.95
- CADD 25.40
- PolyPhen-2 1.00
- SIFT 0.00
- Population evidence available
- Structural context available
- Literature evidence available