W73C (p.Trp73Cys) variant of PRNP (Major prion protein)
W73C (p.Trp73Cys) in PRNP (Major prion protein) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.70 / 1. The record also includes population frequency data and structural context.
W73C (p.Trp73Cys) variant details
- p.Trp73Cys
- TOPMed rs929341781
- gnomAD rs929341781
- Missense
- Variant Prioritization Score for Impact Estimate 0.704
- REVEL 0.75
- CADD 23.80
- PolyPhen-2 1.00
- SIFT 0.07
- Population evidence available
- Structural context available