W31R (p.Trp31Arg) variant of PRNP (Major prion protein)
W31R (p.Trp31Arg) in PRNP (Major prion protein) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.42 / 1. The record also includes population frequency data and structural context.
W31R (p.Trp31Arg) variant details
- p.Trp31Arg
- gnomAD rs1360068809
- Missense
- Variant Prioritization Score for Impact Estimate 0.422
- REVEL 0.48
- CADD 23.50
- PolyPhen-2 0.07
- SIFT 0.02
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available