T15A (p.Thr15Ala) variant of PRNP (Major prion protein)
T15A (p.Thr15Ala) in PRNP (Major prion protein) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.30 / 1. The record also includes population frequency data, published literature, and structural context.
T15A (p.Thr15Ala) variant details
- p.Thr15Ala
- gnomAD 20-4699263-A-G
- Missense
- Variant Prioritization Score for Impact Estimate 0.299
- REVEL 0.25
- CADD 15.10
- PolyPhen-2 0.03
- SIFT 0.31
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- Literature evidence available