R37G (p.Arg37Gly) variant of PRNP (Major prion protein)
R37G (p.Arg37Gly) in PRNP (Major prion protein) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.63 / 1. The record also includes population frequency data and structural context.
R37G (p.Arg37Gly) variant details
- p.Arg37Gly
- ExAC rs11538763
- gnomAD rs11538763
- Missense
- Variant Prioritization Score for Impact Estimate 0.632
- REVEL 0.65
- CADD 25.60
- PolyPhen-2 1.00
- SIFT 0.01
- Most common in the Latino/Admixed American population (allele frequency 2.2e-05)
- Structural context available