Q67K (p.Gln67Lys) variant of PRNP (Major prion protein)
Q67K (p.Gln67Lys) in PRNP (Major prion protein) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.61 / 1. The record also includes population frequency data and structural context.
Q67K (p.Gln67Lys) variant details
- p.Gln67Lys
- TOPMed rs1415471911
- Missense
- Variant Prioritization Score for Impact Estimate 0.606
- REVEL 0.54
- CADD 21.70
- PolyPhen-2 0.98
- SIFT 0.31
- Most common in the Non-Finnish European population (allele frequency 6.3e-06)
- Structural context available