P60T (p.Pro60Thr) variant of PRNP (Major prion protein)
P60T (p.Pro60Thr) in PRNP (Major prion protein) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.57 / 1. The record also includes population frequency data, published literature, and structural context.
P60T (p.Pro60Thr) variant details
- p.Pro60Thr
- gnomAD 20-4699398-C-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.573
- REVEL 0.65
- CADD 24.30
- PolyPhen-2 0.83
- SIFT 0.03
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- Literature evidence available