P51S (p.Pro51Ser) variant of PRNP (Major prion protein)
P51S (p.Pro51Ser) in PRNP (Major prion protein) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.42 / 1. The record also includes population frequency data and structural context.
P51S (p.Pro51Ser) variant details
- p.Pro51Ser
- TOPMed rs760774153
- gnomAD rs760774153
- Missense
- Variant Prioritization Score for Impact Estimate 0.417
- REVEL 0.36
- CADD 19.40
- PolyPhen-2 0.12
- SIFT 0.15
- Most common in the REMAINING population (allele frequency 3.3e-05)
- Structural context available