P39S (p.Pro39Ser) variant of PRNP (Major prion protein)
P39S (p.Pro39Ser) in PRNP (Major prion protein) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.72 / 1. The record also includes population frequency data and structural context.
P39S (p.Pro39Ser) variant details
- p.Pro39Ser
- ESP rs11538756
- TOPMed rs11538756
- gnomAD rs11538756
- Missense
- Variant Prioritization Score for Impact Estimate 0.724
- REVEL 0.70
- CADD 23.40
- PolyPhen-2 0.87
- SIFT 0.15
- Most common in the REMAINING population (allele frequency 1.7e-05)
- Structural context available