P28S (p.Pro28Ser) variant of PRNP (Major prion protein)
P28S (p.Pro28Ser) in PRNP (Major prion protein) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.56 / 1. The record also includes population frequency data and structural context.
P28S (p.Pro28Ser) variant details
- p.Pro28Ser
- TOPMed rs1369247240
- gnomAD rs1369247240
- Missense
- Variant Prioritization Score for Impact Estimate 0.556
- REVEL 0.49
- CADD 22.90
- Most common in the Non-Finnish European population (allele frequency 1.5e-05)
- Structural context available