M8V (p.Met8Val) variant of PRNP (Major prion protein)
M8V (p.Met8Val) in PRNP (Major prion protein) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.27 / 1. The record also includes population frequency data and structural context.
M8V (p.Met8Val) variant details
- p.Met8Val
- ExAC rs760925175
- gnomAD rs760925175
- Missense
- Variant Prioritization Score for Impact Estimate 0.266
- REVEL 0.28
- CADD 10.30
- PolyPhen-2 0.00
- SIFT 0.03
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available