L21L (p.Leu21Leu) variant of PRNP (Major prion protein)
L21L (p.Leu21Leu) in PRNP (Major prion protein) is a synonymous change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.31 / 1. The record also includes population frequency data, published literature, and structural context.
L21L (p.Leu21Leu) variant details
- p.Leu21Leu
- gnomAD 20-4699283-C-T
- Synonymous
- Variant Prioritization Score for Impact Estimate 0.307
- CADD 8.37
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- Literature evidence available