L19V (p.Leu19Val) variant of PRNP (Major prion protein)
L19V (p.Leu19Val) in PRNP (Major prion protein) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.17 / 1. The record also includes population frequency data and structural context.
L19V (p.Leu19Val) variant details
- p.Leu19Val
- TOPMed rs1261971734
- gnomAD rs1261971734
- Missense
- Variant Prioritization Score for Impact Estimate 0.17
- REVEL 0.24
- CADD 0.01
- PolyPhen-2 0.00
- SIFT 1.00
- Most common in the Non-Finnish European population (allele frequency 1.5e-05)
- Structural context available