K24R (p.Lys24Arg) variant of PRNP (Major prion protein)
K24R (p.Lys24Arg) in PRNP (Major prion protein) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.59 / 1. The record also includes population frequency data and structural context.
K24R (p.Lys24Arg) variant details
- p.Lys24Arg
- Ensembl rs1197612803
- Missense
- Variant Prioritization Score for Impact Estimate 0.586
- REVEL 0.55
- CADD 25.80
- PolyPhen-2 1.00
- SIFT 0.01
- Most common in the East Asian population (allele frequency 2.5e-05)
- Structural context available